• Crack Cocaine Side Effects

Crack cocaine is an easier-to-manufacture form of freebase cocaine – the only difference between cocaine and crack is that the latter has its hydrochloride removed, increasing the melting point and making the drug smokable. Because its production doesn't require the use of flammable solvents, it is safer to make than freebase cocaine. Benzoylecgonine is the main cocaine metabolite used in drug testing because it has a urine concentration 50 to 100 times greater than the concentration of cocaine. 4 Does Cocaine Stay in Your System Longer if It’s Combined With Alcohol?

Crack cocaine, also known simply as crack or rock, is a free base form of cocaine that can be smoked. Crack offers a short but intense high to smokers. The Manual of Adolescent Substance Abuse Treatment calls it the most addictive form of cocaine.^[1] Crack first saw widespread use as a recreational drug in primarily impoverishedinner city neighborhoods in New York, Philadelphia, Baltimore, Washington, D.C., Los Angeles, and Miami in late 1984 and 1985; its rapid increase in use and availability is sometimes termed as the 'crack epidemic'.^[2]

• 1Physical and chemical properties
• 3Adverse effects
  • 3.1Physiological
  • 3.4Reinforcement disorders
• 5Society and culture
  • 5.4Legal status

Physical and chemical properties

In purer forms, crack rocks appear as off-white nuggets with jagged edges,^[3] with a slightly higher density than candle wax. Purer forms of crack resemble a hard plastic in crystalline form, which is brittle^[3] (pieces snap when they are broken). A crack rock acts as a local anesthetic (see: cocaine), numbing the tongue or mouth only where directly placed. Purer forms of crack will sink in water or melt at the edges when near a flame (crack vaporizes at 90 °C, 194 °F).^[1]

Crack cocaine as sold on the streets may be adulterated or 'cut' with other substances mimicking the appearance of crack cocaine to increase bulk. Use of toxic adulterants such as levamisole^[4] has been documented.^[5]

Synthesis

Sodium bicarbonate (NaHCO₃, common baking soda) is a base used in preparation of crack, although other weak bases may substitute for it.^[6][7] The net reaction when using sodium bicarbonate is

Coc-H⁺Cl⁻ + NaHCO₃ → Coc + H₂O + CO₂ + NaCl

With ammonium bicarbonate:

Coc-H⁺Cl⁻ + NH₄HCO₃ → Coc + NH₄Cl + CO₂ + H₂O

With ammonium carbonate:

2(Coc-H⁺Cl⁻) + (NH₄)₂CO₃ → 2 Coc + 2 NH₄Cl + CO₂ + H₂O

Crack cocaine is frequently purchased already in rock form,^[3] although it is not uncommon for some users to 'wash up' or 'cook' powder cocaine into crack themselves. This process is frequently done with baking soda (sodium bicarbonate), water, and a spoon. Once mixed and heated, the bicarbonate reacts with the hydrochloride of the powder cocaine, forming free base cocaine and carbonic acid (H₂CO₃) in a reversible acid-base reaction. The heating accelerates the degradation of carbonic acid into carbon dioxide (CO₂) and water. Loss of CO₂ prevents the reaction from reversing back to cocaine hydrochloride. Free base cocaine separates as an oily layer, floating on the top of the now leftover aqueous phase. It is at this point that the oil is picked up rapidly, usually with a pin or long thin object. This pulls the oil up and spins it, allowing air to set and dry the oil, and allows the maker to roll the oil into the rock-like shape.

Crack vaporizes near temperature 90 °C (194 °F),^[1] much lower than the cocaine hydrochloride melting point of 190 °C (374 °F).^[1] Whereas cocaine hydrochloride cannot be smoked (burns with no effect),^[1]crack cocaine when smoked allows for quick absorption into the blood stream, and reaches the brain in eight seconds.^[1] Crack cocaine can also be injected intravenously with the same effect as powder cocaine. However, whereas powder cocaine dissolves in water, crack must be dissolved in an acidic solution such as lemon juice or white vinegar, a process that effectively reverses the original conversion of powder cocaine to crack.

Recreational use

Crack cocaine is commonly used as a recreational drug. Effects of crack cocaine include euphoria,^[8] supreme confidence,^[9] loss of appetite,^[8]insomnia,^[8] alertness,^[8] increased energy,^[8] a craving for more cocaine,^[9]and potential paranoia (ending after use).^[8][10]Its initial effect is to release a large amount of dopamine,^[3] a brain chemical inducing feelings of euphoria. The high usually lasts from 5–10 minutes,^[3][8] after which time dopamine levels in the brain plummet, leaving the user feeling depressed and low.^[3] When (powder) cocaine is dissolved and injected, the absorption into the bloodstream is at least as rapid as the absorption of the drug which occurs when crack cocaine is smoked,^[8] and similar euphoria may be experienced.

Adverse effects

Because crack is an illicit drug, users may consume impure or fake ('bunk') drug,^[5] which may pose additional health risks.

Physiological

The short-term physiological effects of cocaine include^[8] constricted blood vessels, dilated pupils, and increased temperature, heart rate, and blood pressure. Some users of cocaine report feelings of restlessness, irritability, and anxiety. In rare instances, sudden death can occur on the first use of cocaine or unexpectedly thereafter.^[8] Cocaine-related deaths are often a result of cardiac arrest or seizures followed by respiratory arrest.

Like other forms of cocaine, smoking crack can increase heart rate^[11] and blood pressure, leading to long-term cardiovascular problems. Some research suggests that smoking crack or freebase cocaine has additional health risks compared to other methods of taking cocaine. Many of these issues relate specifically to the release of methylecgonidine and its effect on the heart,^[11] lungs,^[12] and liver.^[13]

Build the Bridge: Train Game, Use your master mason skills to help this train reach its destination safely! Build a train game. Should the player's train cross the bridge successfully and under budget, the level is passed. Later games add additional constraints such as a boat that must pass underneath between two consecutive train crossings. Although Bridge Builder only allows the player steel beams, bridges in later installments can be created. The concept of Bridge Building Game is still the same as in the calssic game: Your task is to build a bridge which has to support a passing train and stay undamaged. Actually, it doesn't necessarily have to stay undamaged, the train just has to pass to the other side safely. Each bridge element is $100 and your budget is. Build the Bridge at Cool Math Games: Your goal is to use the pieces provided to create a safe path for the train to travel across to the tunnel. This is the SLJ900/32 Bridge Girder Erection Machine working away in China. It's a substitute for large.

• Toxic adulterants: Many substances may have been added in order to expand the weight and volume of a batch, while still appearing to be pure crack. Occasionally, highly toxic substances are used, with a range of corresponding short and long-term health risks. Adulturants used with crack and cocaine include milk powder, sugars such as glucose, starch, caffeine, lidocaine, benzocaine, paracetamol, amphetamine, scopolamine and strychnine.^[14]
• Smoking problems: Any route of administration poses its own set of health risks; in the case of crack cocaine, smoking tends to be more harmful than other routes. Crack users tend to smoke the drug because that has a higher bioavailability than other routes typically used for drugs of abuse such as insufflation.^{[citation needed]} Crack has a melting point of around 90 °C(194 °F),^[1] and the smoke does not remain potent for long. Therefore, crack pipes are generally very short, to minimize the time between evaporating and ingestion (thereby minimizing loss of potency).^{[citation needed]} Having a very hot pipe pressed against the lips often causes cracked and blistered lips, colloquially known as 'crack lip'. The use of 'convenience store crack pipes'^[15] – glass tubes which originally contained small artificial roses – may contribute to this condition. These 4-inch (10-cm) pipes^[15] are not durable and will quickly develop breaks; users may continue to use the pipe even though it has been broken to a shorter length. The hot pipe might burn the lips, tongue, or fingers, especially when passed between people who take hits in rapid succession, causing the short pipe to reach higher temperatures than if used by one person alone.
• Pure or large doses: Because the quality of crack can vary greatly, some people might smoke larger amounts of diluted crack, unaware that a similar amount of a new batch of purer crack could cause an overdose. This can trigger heart problems or cause unconsciousness.
• Pathogens on pipes: When pipes are shared, bacteria or viruses can be transferred from person to person.

Crack lung

In crack users, acute respiratory symptoms have been reported, sometimes termed crack lung. Symptoms include fever, coughing up blood and difficulty breathing.^[16] In the 48-hour period after use, people with these symptoms have also had associated radiographic findings on chest X-ray of fluid in the lungs (pulmonary edema), interstitial pneumonia, diffuse alveolar hemorrhage, and eosinophil infiltration.^[16]

Psychological

Stimulant drug abuse (particularly amphetamine and cocaine) can lead to delusional parasitosis (aka Ekbom's Syndrome: a mistaken belief they are infested with parasites).^[17] For example, excessive cocaine use can lead to formication, nicknamed 'cocaine bugs' or 'coke bugs', where the affected people believe they have, or feel, parasites crawling under their skin.^[17] (Similar delusions may also be associated with high fever or in connection with alcohol withdrawal, sometimes accompanied by visual hallucinations of insects.)^[17]

People experiencing these hallucinations might scratch themselves to the extent of serious skin damage and bleeding, especially when they are delirious.^[10][17]

Paranoia and anxiety are among the most common psychological symptoms of crack cocaine use. Psychosis is more closely associated with smoking crack cocaine than intranasal and intravenous use.^[18]

Pregnancy and nursing

Crack baby is a term for a child born to a mother who used crack cocaine during her pregnancy. The threat that cocaine use during pregnancy poses to the fetus is now considered exaggerated.^[19] Studies show that prenatal cocaine exposure (independent of other effects such as, for example, alcohol, tobacco, or physical environment) has no appreciable effect on childhood growth and development.^[20]However, the official opinion of the National Institute on Drug Abuse of the United States warns about health risks while cautioning against stereotyping:

Many recall that 'crack babies', or babies born to mothers who used crack cocaine while pregnant, were at one time written off by many as a lost generation. They were predicted to suffer from severe, irreversible damage, including reduced intelligence and social skills. It was later found that this was a gross exaggeration. However, the fact that most of these children appear normal should not be over-interpreted as indicating that there is no cause for concern. Using sophisticated technologies, scientists are now finding that exposure to cocaine during fetal development may lead to subtle, yet significant, later deficits in some children, including deficits in some aspects of cognitive performance, information-processing, and attention to tasks—abilities that are important for success in school.^[21]

There are also warnings about the threat of breastfeeding: The March of Dimes said 'it is likely that cocaine will reach the baby through breast milk,' and advises the following regarding cocaine use during pregnancy:

Cocaine use during pregnancy can affect a pregnant woman and her unborn baby in many ways. During the early months of pregnancy, it may increase the risk of miscarriage. Later in pregnancy, it can trigger preterm labor (labor that occurs before 37 weeks of pregnancy) or cause the baby to grow poorly. As a result, cocaine-exposed babies are more likely than unexposed babies to be born with low birthweight (less than 5.5 lb or 2.5 kg). Low-birthweight babies are 20 times more likely to die in their first month of life than normal-weight babies, and face an increased risk of lifelong disabilities such as mental retardation and cerebral palsy. Cocaine-exposed babies also tend to have smaller heads, which generally reflect smaller brains. Some studies suggest that cocaine-exposed babies are at increased risk of birth defects, including urinary-tract defects and, possibly, heart defects. Cocaine also may cause an unborn baby to have a stroke, irreversible brain damage, or a heart attack.^[22]

Reinforcement disorders

Tolerance

An appreciable tolerance to cocaine's high may develop, with many addicts reporting that they seek but fail to achieve as much pleasure as they did from their first experience.^[8] Some users will frequently increase their doses to intensify and prolong the euphoric effects. While tolerance to the high can occur, users might also become more sensitive (drug sensitization) to cocaine's local anesthetic (pain killing) and convulsant (seizure inducing) effects, without increasing the dose taken; this increased sensitivity may explain some deaths occurring after apparent low doses of cocaine.^[8]

Addiction

Crack cocaine is popularly thought to be the most addictive form of cocaine.^[1] However, this claim has been contested: Morgan and Zimmer wrote that available data indicated that '..smoking cocaine by itself does not increase markedly the likelihood of dependence.. The claim that cocaine is much more addictive when smoked must be reexamined.'^[23] They argued that cocaine users who are already prone to abuse are most likely to 'move toward a more efficient mode of ingestion' (that is, smoking).

The intense desire to recapture the initial high is what is so addictive for many users.^[3] On the other hand, Reinarman et al. wrote that the nature of crack addiction depends on the social context in which it is used and the psychological characteristics of users, pointing out that many heavy crack users can go for days or weeks without using the drugs.^[24]

Overdose

Crack Cocaine Side Effects

A typical response among users is to have another hit of the drug; however, the levels of dopamine in the brain take a long time to replenish themselves, and each hit taken in rapid succession leads to progressively less intense highs.^[3] However, a person might binge for 3 or more days without sleep, while inhaling hits from the pipe.^[10]

Use of cocaine in a binge, during which the drug is taken repeatedly and at increasingly high doses, leads to a state of increasing irritability, restlessness, and paranoia.^[8] This may result in a full-blown paranoid psychosis, in which the individual loses touch with reality and experiences auditory hallucinations.^[8]

Large amounts of crack cocaine (several hundred milligrams or more) intensify the user's high, but may also lead to bizarre, erratic, and violent behavior.^[8] Large amounts can induce tremors, vertigo, muscle twitches, paranoia, or, with repeated doses, a toxic reaction closely resembling amphetamine poisoning.^[8]

Society and culture

Synonyms

atari; base; bazooka; beamers; beemers; bebe; bee-bee; berry; bing; bolo; bomb; boulder; boulders; butter; caine; cane; Casper; Casper the ghost; cavvy; chemical; chewies; cloud; cloud nine; crills; crunch and munch; dip; famous dimes; fan; fish scale; fries; fry; glo; golfball; gravel; grit; hail; hamburger; helper; hubba; ice cube; kangaroo; kibbles and bits; kibbles; krills; lightem; paste; patico; pebbles; pee wee; pony; raw; ready; ready rocks; redi rocks; roca; rock; rooster; rox; Roxanne; scud; Scotty; scramble; scruples; seven-up; sherm; sherms; sleet; snowballs; stones; teeth; tension; top gun; tweak; ultimate; wash; white cloud; work; yahoo; yale; yay; yayoo; yeah-O; yeyo; yeo; yuck.^[25]

Drug combinations

Crack cocaine may be combined with amphetamine ('croack'); tobacco ('coolie'); marijuana ('buddha'; 'caviar'; 'chronic'; 'cocoa puffs'; 'fry daddy'; 'gimmie'; 'gremmie'; 'juice'; 'primo'; 'torpedo'; 'turbo'; 'woolie'; 'woola'); heroin ('moon rock'); and phencyclidine ('clicker'; 'p-funk'; 'spacebase').^[25]

Consumption

Crack smoking ('hitting the pipe'; 'puffing'; 'beaming up (to Scotty)') is commonly performed with utensils such as pipes ('bowl'; 'devil's dick'; 'glass dick'; 'horn'; 'Uzi'); improvised pipes made from a plastic bottle ('Masarati'); water pipes ('bong'; 'hubbly-bubbly'); and laboratory pipettes ('demo').^[25]

Legal status

Cocaine is listed as a Schedule I drug in the United Nations 1961 Single Convention on Narcotic Drugs, making it illegal for non-state-sanctioned production, manufacture, export, import, distribution, trade, use and possession.^[26] In most states (except in the U.S.) crack falls under the same category as cocaine.

Australia

In Australia, crack falls under the same category as cocaine, which is listed as a Schedule 8 controlled drug, indicating that any substances and preparations for therapeutic use under this category have high potential for abuse and addiction. It is permitted for some medical use, but is otherwise outlawed.

Canada

As a Schedule I substance under the Controlled Drugs and Substances Act, crack is not differentiated from cocaine and other coca products. However, the court may weigh the socio-economic factors of crack usage in sentencing. As a guideline, Schedule I drugs carry a maximum 7-year prison sentence for possession for an indictable offense and up to life imprisonment for trafficking and production. A summary conviction on possession carries a $1000–$2000 fine and/or 6 months to a year imprisonment.

United States

In the United States, cocaine is a Schedule II drug under the Controlled Substances Act, indicating that it has a high abuse potential but also carries a medicinal purpose.^[27][28] Under the Controlled Substances Act, crack and cocaine are considered the same drug.

The Anti-Drug Abuse Act of 1986 increased penalties for crack cocaine possession and usage. It mandated a mandatory minimum sentence of five years without parole for possession of five grams of crack; to receive the same sentence with powder cocaine one had to have 500 grams.^[29] This sentencing disparity was reduced from 100-to-1 to 18-to-1 by the Fair Sentencing Act of 2010.

Europe

In the United Kingdom, crack is a Class A drug under the Misuse of Drugs Act 1971. In the Netherlands it is a List 1 drug of the Opium Law.

Political scandals

Rob Ford, the 64th mayor of Toronto, was filmed smoking crack while he was in office. Marion Barry, Mayor of Washington D.C., was filmed smoking crack in 1990 in a sting operation.^[30]

See also

• Cocaine paste ('paco')
• Structurally related chemicals: proparacaine, tetracaine, lidocaine, procaine, hexylcaine, bupivacaine, benoxinate, mepivacaine, prilocaine, etidocaine, benzocaine, chloroprocaine, propoxycaine, dyclonine, dibucaine, and pramoxine.

References

1. ^ ^abcdefghManual of Adolescent Substance Abuse Treatment, Todd Wilk Estroff, M.D., 2001 (306 pages), pp. 44–45, (describes cocaine/crack processing & melting points): p.44 has 'cannot be smoked because..melting point of 190 °C'; p.45 has 'It is the most addictive form of cocaine', webpage: [1], p. 44, at Google Books
2. ^Reinarman, Craig; Levine, Harry G. (1997). 'Crack in Context: America's Latest Demon Drug'. In Reinarman, Craig; Levine, Harry G. (eds.). Crack in America: Demon Drugs and Social Justice. Berkeley, CA: University of California Press.
3. ^ ^abcdefghA.M. Costa Rica, July 2008, Crack rocks offer a short but intense high to smokers.
4. ^Kinzie, Erik (April 2009). 'Levamisole Found in Patients Using Cocaine'. Annals of Emergency Medicine. 53 (4). Retrieved 2009-08-18.
5. ^ ^ab'Officials warn of life-threatening cocaine in area', Stacy O'Brien, Red Deer Advocate, December 2008, webpage: reddeer-officials^{[permanent dead link]}: notes cocaine with the worming medicine levamisole.
6. ^Treadwell, SD; Robinson, TG (June 2007). 'Cocaine use and stroke'. Postgraduate Medical Journal (Review). 83 (980): 389–94. doi:10.1136/pgmj.2006.055970. PMC2600058. PMID17551070.
7. ^'Cocaine Abuse & Addiction'. www1.nyc.gov. City of New York.
8. ^ ^{abcdefghijklmnop}'DEA, Drug Information, Cocaine', United States DOJ Drug Enforcement Administration, 2008, webpage: DEA-cocaineArchived 2008-06-22 at the Wayback Machine.
9. ^ ^abWhite Mischief: A Cultural History of Cocaine, Tim Madge, 2004, ISBN1-56025-370-3, link: [2], p. 18, at Google Books.
10. ^ ^abc 'Life or Meth – CRACK OF THE 90'S', Salt Lake City Police Department, Utah, 2008, PDF file: Methlife-PDFArchived 2007-10-31 at the Wayback Machine.
11. ^ ^abScheidweiler KB, Plessinger MA, Shojaie J, Wood RW, Kwong TC (2003). 'Pharmacokinetics and pharmacodynamics of methylecgonidine, a crack cocaine pyrolyzate'. Journal of Pharmacology and Experimental Therapeutics. 307 (3): 1179–1187. doi:10.1124/jpet.103.055434. PMID14561847. Retrieved 2008-02-24.
12. ^Yang Y, Ke Q, Cai J, Xiao YF, Morgan JP (2001). 'Evidence for cocaine and methylecgonidine stimulation of M(2) muscarinic receptors in cultured human embryonic lung cells'. British Journal of Pharmacology. 132 (2): 451–460. doi:10.1038/sj.bjp.0703819. PMC1572570. PMID11159694.
13. ^Fandiño AS, Toennes SW, Kauert GF (2002). 'Studies on hydrolytic and oxidative metabolic pathways of anhydroecgonine methyl ester (methylecgonidine) using microsomal preparations from rat organs'. Chemical Research in Toxicology. 15 (12): 1543–1548. doi:10.1021/tx0255828. PMID12482236.
14. ^Cole, Claire; Jones, Lisa; McVeigh, Jim; Kicman, Andrew; Syed, Qutub; Belis, Mark A. (2010). Cut: A Guide to Adulturants, Bulkinh Agents and other Contaminants found in Illicit Drugs. Centre for Public Health, Liverpool John Moores University. pp. 6–25.
15. ^ ^abLengel, Allan (April 5, 2006). 'A Rose With Another Name: Crack Pipe'. The Washington Post. Retrieved May 28, 2017.
16. ^ ^abMégarbane, B; Chevillard, L (5 December 2013). 'The large spectrum of pulmonary complications following illicit drug use: features and mechanisms'. Chemico-Biological Interactions. 206 (3): 444–51. doi:10.1016/j.cbi.2013.10.011. PMID24144776.
17. ^ ^abcd 'Delusional Parasitosis', The Bohart Museum of Entomology, 2005, webpage: UCDavis-delusional^{[permanent dead link]}.
18. ^Morton, W. Alexander (August 1999). 'Cocaine and Psychiatric Symptoms'. Primary Care Companion to the Journal of Clinical Psychiatry. 1 (4): 109–113. doi:10.4088/pcc.v01n0403. PMC181074. PMID15014683.
19. ^Okie, Susan (2009-01-27). 'The Epidemic That Wasn't'. The New York Times.
20. ^'Growth, Development, and Behavior in Early Childhood Following Prenatal Cocaine Exposure, Frank et al. 285 (12): 1613 – JAMA'. Jama.ama-assn.org. 2001-03-28. Retrieved 2010-12-22.
21. ^NIDA – Research Report Series – Cocaine Abuse and AddictionArchived September 26, 2007, at the Wayback Machine
22. ^'Street Drugs and pregnancy'. March of Dimes. Retrieved 2009-05-26.
23. ^Morgan, John P.; Zimmer, Lynn (1997). 'Social Pharmacology of Smokeable Cocaine'. In Reinarman, Craig; Levine, Harry G. (eds.). Crack in America: Demon Drugs and Social Justice. Berkeley, Ca.: University of California Press.
24. ^Reinarman, Craig; Waldorf, Dan; Murphy, Sheigla B.; Levine, Harry G. (1997). 'The Contingent Call of the Pipe: Bingeing and Addiction Among Heavy Cocaine Smokers'. In Reinarman, Craig; Levine, Harry G. (eds.). Crack in America: Demon Drugs and Social Justice. Berkeley, Ca.: University of California Press.
25. ^ ^abcTom Dalzell (2009), The Routledge Dictionary of Modern American Slang and Unconventional English, Routledge, ISBN978-0-415-37182-7
26. ^'Single Convention on Narcotic Drugs, 1961'(PDF). International Narcotics Control Board. Archived from the original(PDF) on 2008-05-09. Retrieved 2008-05-01.Cite uses deprecated parameter deadurl= (help)
27. ^'DEA, Title 21, Section 812'. Usdoj.gov. Archived from the original on 2008-08-22. Retrieved 2008-09-05.
28. ^21 U.S.C.§ 812(b)(2)Retrieved 2008-05-01.
29. ^Sterling, Eric. 'Drug Laws and Snitching: A Primer'. PBS. Retrieved 20 May 2013.
30. ^LaFraniere, Sharon (January 19, 1990). 'Barry Arrested on Cocaine Charges in Undercover FBI, Police Operation'. The Washington Post. p. A1.

Further reading

• Cooper, Edith Fairman, The emergence of crack cocaine abuse, Nova Publishers, 2002